Analysis of dry granulator and dry granulation technology

With the deepening of the concept that quality comes from design, the pharmaceutical industry pays more and more attention to the R & D and pilot production of pharmaceutical production technology, aiming to solve the current situation of many problems in the process of pharmaceutical production process from experimental scale-up to mass production.

Dry granulation machine is a new granulation method developed after the second generation granulation method, which is a new equipment for directly pressing powder into granules. Dry granulator is widely used in pharmaceutical, food, chemical and other industries.

The machine has the advantages of compact structure, convenient maintenance, simple operation, short process flow, low energy consumption, high efficiency and low failure rate. It can control environmental pollution, reduce powder waste and packaging cost, and improve the product transportation capacity. Made of stainless steel, titanium, chromium and other surface alloys, the wear resistance, corrosion resistance, high temperature resistance and pressure resistance are greatly improved, and the machine has a long service life.

It is understood that the dry granulator uses the latest roller control technology. The control equipment of the equipment can adjust the fluctuation of any physical property (such as local non-uniformity) between different materials and different batches of the same material, so that the process parameters of dry granulation (such as processing capacity, sheet density, rolling pressure, speed, etc.) can be accurately and repeatedly adjusted, so as to efficiently and effectively High quality particles are produced.

The dry granulation technology can be completed by roller flat pressure granulator. A certain relative density of traditional Chinese medicine extract is obtained by spray drying to extract dry extract powder. After adding certain excipients, the dry extruding granulator is pressed into thin slices and then crushed into granules. The raw materials of powder can be directly made into granular products meeting the requirements of customers without any intermediate and additives. After granulation, the particle size of the finished product is uniform and the bulk density is increased significantly; dust pollution is controlled and material waste is reduced; the appearance and fluidity of materials are improved; the volume is reduced to facilitate storage and transportation; the solubility, porosity and specific surface area can be controlled.

Experts say dry granulating technology has no spray drying technology, and spray drying technology is relatively mature. Dry granulation has a good development prospect, but the technical difficulty is also very big, we must rely on the joint participation of government departments, more industry research institutions and equipment manufacturers.